Description

1-[5-(Trifluoromethyl)Pyridin-2-Yl]Piperazine is a high-value, nitrogen-containing heterocyclic building block featuring a piperazine ring linked to a trifluoromethyl-substituted pyridine. This molecular architecture makes it a critical intermediate for the synthesis of advanced pharmaceutical compounds and agrochemicals, where the trifluoromethyl group is prized for its ability to modulate lipophilicity, metabolic stability, and bioavailability. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) drugs, kinase inhibitors, and anti-infective agents.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethylpyridine moiety.
• Ligand & Catalyst Development: Serves as a precursor for nitrogen-donor ligands in coordination chemistry and catalysis for organic transformations.
• Material Science Research: Investigated as a monomer or functional additive for advanced polymers and functional materials.
• Chemical Biology & Proteomics: Utilized as a scaffold or linker in the design of molecular probes and biochemical tools.
• Custom Synthesis & Contract Manufacturing: A pivotal starting material for custom synthesis projects and scale-up manufacturing under cGMP or ISO standards.

Basic Information

Item	Details
Product Name	1-[5-(Trifluoromethyl)Pyridin-2-Yl]Piperazine
CAS No.	132834-58-3
Molecular Formula	C10H12F3N3
Molecular Weight	231.22 g/mol
Synonyms	2-(1-Piperazinyl)-5-(trifluoromethyl)pyridine; 5-(Trifluoromethyl)-2-piperazin-1-ylpyridine; 1-(5-Trifluoromethyl-2-pyridyl)piperazine; 2-Piperazin-1-yl-5-trifluoromethylpyridine; 5-(Trifluoromethyl)-2-(1-piperazinyl)pyridine; 1-(5-(Trifluoromethyl)pyridin-2-yl)piperazine; 2-(Piperazin-1-yl)-5-(trifluoromethyl)pyridine
EINECS	Contact for details

Quality Control

Our 1-[5-(Trifluoromethyl)Pyridin-2-Yl]Piperazine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports applications requiring high-purity intermediates for research and cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.