Description

D-Glutamic Acid, 4-Fluoro-, (4S)- (9Ci) is a high-purity, non-natural amino acid derivative featuring a fluorine atom at the 4-position of the glutamic acid backbone. This specific stereochemistry and fluorination make it a critical building block for advanced pharmaceutical research and peptide synthesis, offering unique metabolic stability and binding properties. It is primarily needed by research institutions, pharmaceutical developers, and fine chemical manufacturers engaged in drug discovery, proteomics, and the development of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic and neurological targets.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate fluorinated glutamic acid residues, modifying peptide stability, conformation, and receptor interaction.
• Biochemical Research: Serves as a tool compound in enzyme inhibition studies, metabolic pathway analysis, and structure-activity relationship (SAR) investigations.
• Proteomics & Labeling: Potential use in the design of probes and labels for studying protein function and interactions due to the fluorine atom's utility in 19F NMR spectroscopy.
• Agrochemical Research: Exploration of novel, biologically active compounds for crop protection and enhancement.

Basic Information

Product Name	D-Glutamic Acid, 4-Fluoro-, (4S)- (9Ci)
CAS No.	132746-47-5
Molecular Formula	C5H8FNO4
Molecular Weight	165.12 g/mol
Synonyms	(2S)-2-Amino-4-fluoropentanedioic acid; D-4-Fluoroglutamic acid; (S)-2-Amino-4-fluoroglutaric acid; 4-Fluoro-D-glutamic acid; (4S)-4-Fluoroglutamic acid; FLUORO-DL-GLUTAMIC ACID (isomeric mixture); 4-Fluoro-L-glutamic acid (enantiomer); 132746-47-5
EINECS	Contact for details

Quality Control

Our D-Glutamic Acid, 4-Fluoro-, (4S)- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) detailing purity, identity, and specific tests are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly closed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.