Description

44-Homooligomycin A is a specialized macrolide compound belonging to the oligomycin family, a class of potent mitochondrial ATP synthase inhibitors. This high-purity reference standard is critical for biochemical research and pharmaceutical development, enabling precise study of cellular energy metabolism and ion transport mechanisms. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic manufacturers focused on metabolic disorders, cancer research, and mitochondrial function analysis.

Application

• Biochemical Research: Used as a specific inhibitor of the mitochondrial F1F0-ATP synthase (Complex V) to study oxidative phosphorylation, cellular bioenergetics, and ion homeostasis.
• Pharmaceutical R&D: Serves as a key reference standard and pharmacological tool in drug discovery programs targeting metabolic diseases, cancer metabolism, and conditions involving mitochondrial dysfunction.
• Cell Biology Studies: Employed to induce mitochondrial membrane potential collapse and study apoptosis, autophagy, and other cell death pathways in various cell lines.
• Diagnostic Assay Development: Utilized in the development and validation of in vitro diagnostic (IVD) kits and assays designed to measure mitochondrial function and ATP production.
• Agricultural Research: Investigated for its potential as a lead compound or biochemical probe in the study of fungal and pest control, leveraging its mode of action on energy metabolism.

Basic Information

Product Name	44-Homooligomycin A
CAS No.	132707-68-7
Molecular Formula	C46H76O13
Molecular Weight	837.1 g/mol
Synonyms	44-Homo-oligomycin A; Homooligomycin A; Oligomycin A, 44-homo-; (3R,5S,7R,8S,9S,10R,11S,13R,14S,16R)-16-[(2R,5S,6S)-5-Ethyl-5,6-dihydro-6-methyl-2H-pyran-2-yl]-5,7,9,11,13,15-hexamethyl-2,10-dioxo-4,17-dioxabicyclo[13.3.1]nonadec-14-yl 2-methylbutanoate; ATP Synthase Inhibitor (Oligomycin analog)
EINECS	Contact for details

Quality Control

Our 44-Homooligomycin A is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications are designed to meet the rigorous demands of pharmaceutical reference material and advanced life science research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.