Description

Bryostatin 1, 35-Demethoxy-26-Deoxy-22,35-Epoxy-26-Oxo-, (22S)- is a semi-synthetic derivative of the naturally occurring bryostatin family of macrocyclic lactones, known for its potent and selective modulation of protein kinase C (PKC) isozymes. This compound is of significant interest for its potential to serve as a high-value biochemical tool and a lead candidate in advanced therapeutic research. It is primarily sought by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in oncology, neuroscience, and immunology studies.

Application

• Biochemical Research: As a potent and selective activator of protein kinase C (PKC) epsilon and delta isoforms for studying intracellular signaling pathways.
• Oncology Research: Investigation of anti-tumor properties, including induction of apoptosis and differentiation in various cancer cell lines.
• Neuroscience Studies: Exploration of neuroprotective effects and potential in enhancing synaptic plasticity and memory function.
• Immunology Research: Study of its role in modulating immune cell activation and cytokine production.
• Drug Discovery & Development: Serving as a lead compound or a pharmacological probe for the development of novel therapeutics targeting PKC.
• Preclinical Studies: Evaluation of pharmacokinetics, pharmacodynamics, and efficacy in animal models of disease.

Basic Information

Product Name	Bryostatin 1, 35-Demethoxy-26-Deoxy-22,35-Epoxy-26-Oxo-, (22S)-
CAS No.	132564-78-4
Molecular Formula	C45H68O15
Molecular Weight	849.0 g/mol
Synonyms	(22S)-Bryostatin 1 derivative; 26-Deoxy-26-oxobryostatin 1; 35-Demethoxy-26-deoxy-22,35-epoxy-26-oxobryostatin 1; 22S-Bryostatin analogue; PKC modulator; Macrocyclic lactone derivative; Bryostatin 1 analog; NSC-D-669356
EINECS	Contact for details

Quality Control

Our Bryostatin 1 derivative is produced under stringent quality management protocols. Each batch is characterized and tested to ensure identity, purity, and consistency, meeting the exacting standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing results from HPLC, NMR, and MS analyses is provided with every shipment to guarantee traceability and reliability for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. The material is hygroscopic and must be kept in a dry environment. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.