Description

2,2-Difluoro-2-Deoxy-Inositol 1,4,5-Trisphosphate is a fluorinated analog of the critical second messenger, inositol 1,4,5-trisphosphate (IP3). This compound is engineered for high-affinity binding and serves as a potent and selective antagonist of IP3 receptors, making it an indispensable tool for probing calcium signaling pathways in cellular physiology. It is primarily utilized by researchers and developers in the fields of biochemical research, pharmaceutical development, and cell biology to study receptor-ligand interactions and signal transduction mechanisms.

Application

• Biochemical Research: A key tool for studying IP3 receptor-mediated calcium release from intracellular stores.
• Pharmaceutical Development: Used in high-throughput screening and validation of drug candidates targeting calcium signaling pathways.
• Cell Biology Studies: Employed to investigate the role of calcium ions in processes like apoptosis, muscle contraction, and neurotransmitter release.
• Enzyme Inhibition Studies: Acts as a stable, hydrolysis-resistant analog to study the kinetics and specificity of phosphatases and kinases.
• Neuroscience Research: Critical for elucidating calcium's role in neuronal communication, synaptic plasticity, and related disorders.
• Diagnostic Reagent Development: Potential use in developing assays for calcium signaling dysfunction.

Basic Information

Product Name	2,2-Difluoro-2-Deoxy-Inositol 1,4,5-Trisphosphate
CAS No.	132488-75-6
Molecular Formula	C6H11F2O15P3
Molecular Weight	466.06 g/mol
Synonyms	2,2-Difluoro-2-deoxy-myo-inositol 1,4,5-trisphosphate; 2-Deoxy-2,2-difluoro-myo-inositol 1,4,5-trisphosphate; 2,2-Difluoro-IP3; IP3 Receptor Antagonist; FD-IP3; myo-Inositol 1,4,5-trisphosphate, 2-deoxy-2,2-difluoro-; 1D-myo-Inositol 1,4,5-trisphosphate, 2-deoxy-2,2-difluoro-
EINECS	Contact for details

Quality Control

Our 2,2-Difluoro-2-Deoxy-Inositol 1,4,5-Trisphosphate is produced under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous internal quality protocols to meet the exacting requirements of the life science research community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at the recommended temperature. Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.