Description

4-Trifluoromethyl-Pyridine-2-Carbaldehyde is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a trifluoromethyl group and an aldehyde functionality, makes it indispensable for introducing specific physicochemical properties into target molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used to develop novel herbicides, fungicides, and insecticides where the trifluoromethyl group improves lipophilicity and biological activity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the development of advanced organic electronic materials, liquid crystals, and functional polymers.
• Chemical Biology Probes: Utilized to synthesize molecular probes for studying enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Trifluoromethyl-Pyridine-2-Carbaldehyde
CAS No.	132470-83-8
Molecular Formula	C7H4F3NO
Molecular Weight	175.11 g/mol
Synonyms	2-Formyl-4-(trifluoromethyl)pyridine; 4-(Trifluoromethyl)pyridine-2-carboxaldehyde; 2-Pyridinecarboxaldehyde, 4-(trifluoromethyl)-; 4-Trifluoromethyl-2-pyridinecarboxaldehyde; α-Trifluoro-picolinaldehyde; 4-Trifluoromethylpicolinaldehyde; 4-CF3-Picolinaldehyde
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethyl-Pyridine-2-Carbaldehyde is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in regulated environments, including cGMP for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.