Description

D-Mannitol-1-13C is a stable isotope-labeled analog of mannitol, where a carbon-13 atom is incorporated at the C-1 position. This high-purity labeled compound is essential for advanced research requiring precise metabolic and pharmacokinetic tracing. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for applications such as internal standards in mass spectrometry and metabolic pathway studies.

Application

• Mass Spectrometry Internal Standard: Serves as a critical quantitative reference standard in LC-MS and GC-MS analysis for accurate measurement of natural D-mannitol in complex biological matrices.
• Metabolic Pathway Tracing: Used in in vitro and in vivo studies to elucidate the absorption, distribution, metabolism, and excretion (ADME) profiles of mannitol and related compounds.
• Pharmaceutical Research & Development: Enables precise drug metabolism and pharmacokinetics (DMPK) studies for new therapeutic agents, particularly those involving sugar alcohol pathways.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: Acts as a probe in 13C-NMR studies to investigate molecular structure, dynamics, and interactions without signal interference from natural abundance carbon.
• Clinical Diagnostic Assays: Employed in the development of high-sensitivity diagnostic tests for renal function and intestinal permeability where mannitol is a marker molecule.
• Isotope Dilution Analysis: Provides the foundation for highly accurate quantification methods in food analysis, environmental testing, and quality control of pharmaceutical formulations.

Basic Information

Product Name	D-Mannitol-1-13C
CAS No.	132202-29-0
Molecular Formula	C613CH14O6
Molecular Weight	183.15 g/mol (approx.)
Synonyms	1-13C-D-Mannitol; D-Mannitol (1-13C); [1-13C]Mannitol; Mannitol-1-13C; (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol-1-13C; 13C Labeled D-Mannitol; Isotopic Mannitol; Mannitol-13C1
EINECS	Contact for details

Quality Control

Our D-Mannitol-1-13C is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including isotopic purity (enrichment) assessment by NMR and mass spectrometry, chemical purity determination by HPLC, and identity confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the exact specifications and results. We support research and compliance needs in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccated conditions to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	13C incorporation at C-1 position confirmed
Assay (HPLC)	≥ 98.0% (chemical purity)
Isotopic Enrichment	≥ 99 atom % 13C
Specific Optical Rotation	[α]20/D: +23° to +25° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.