Description

3'-p-Hydroxy Paclitaxel is a key semi-synthetic derivative of the potent anticancer agent paclitaxel. This compound is a critical intermediate in the development of next-generation taxane-based pharmaceuticals, offering a strategic modification point for enhanced drug delivery and efficacy. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on oncology drug discovery and advanced therapeutic conjugate synthesis.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel paclitaxel analogs and prodrugs with improved solubility or targeted delivery profiles.
• Anticancer Research: Used in biochemical and pharmacological studies to investigate structure-activity relationships (SAR) within the taxane class of compounds.
• Drug Conjugate Development: Serves as a conjugation site for linking to antibodies, polymers, or nanoparticles in the creation of advanced targeted cancer therapies.
• Reference Standard: Employed as a high-purity analytical standard in quality control (QC) and research laboratories for method development and validation.
• Process Chemistry: Integral to scaling up the production of specialized taxane derivatives under current Good Manufacturing Practice (cGMP) conditions.

Basic Information

Product Name	3'-p-Hydroxy Paclitaxel
CAS No.	132160-32-8
Molecular Formula	C47H51NO15
Molecular Weight	869.91 g/mol
Synonyms	3'-p-Hydroxypaclitaxel; 7-Epi-3'-p-Hydroxy Paclitaxel; 3'-para-Hydroxy Paclitaxel; Paclitaxel, 3'-p-hydroxy-; 10-Deacetyl-3'-p-hydroxy Paclitaxel; 3'-Hydroxy Paclitaxel Derivative; Taxol Derivative 3'-p-OH; 3'-p-OH-Paclitaxel
EINECS	Contact for details

Quality Control

Our 3'-p-Hydroxy Paclitaxel is manufactured and tested to meet stringent standards suitable for pharmaceutical research and development. Each batch undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability, consistency, and compliance with your research or process requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.