Description

3-Chlorobicyclo[1.1.1]pentane-1-sulfonyl chloride is a highly functionalized bicyclic building block of significant interest in modern synthetic chemistry. Its unique, rigid [1.1.1]propellane-derived structure and reactive sulfonyl chloride group make it a valuable precursor for introducing the bicyclo[1.1.1]pentane (BCP) motif into target molecules. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and materials science.

Application

• Pharmaceutical Intermediate: Key precursor for synthesizing BCP-containing drug candidates, used to improve metabolic stability, lipophilicity, and three-dimensional character in bioactive molecules.
• Medicinal Chemistry: Serves as a versatile building block for creating novel chemical libraries via amide or sulfonamide formation, enabling structure-activity relationship (SAR) studies.
• Agrochemical Synthesis: Used in the development of advanced crop protection agents where the BCP scaffold can enhance biological activity and environmental profile.
• Materials Science Research: Employed in the synthesis of novel polymers and advanced materials with unique structural and physical properties derived from the strained bicyclic core.
• Cross-Coupling Reactions: Acts as an electrophilic partner in various metal-catalyzed and nucleophilic substitution reactions to incorporate the BCP unit into complex architectures.
• Bioconjugation & Probe Development: Useful for labeling biomolecules or creating chemical probes due to the reactivity of the sulfonyl chloride group.

Basic Information

Product Name	3-Chlorobicyclo[1.1.1]pentane-1-sulfonyl chloride
CAS No.	132145-26-7
Molecular Formula	C5H6Cl2O2S
Molecular Weight	201.07 g/mol
Synonyms	1-(Chlorosulfonyl)-3-chlorobicyclo[1.1.1]pentane; 3-Chloro-1-(chlorosulfonyl)bicyclo[1.1.1]pentane; Bicyclo[1.1.1]pentane-1-sulfonyl chloride, 3-chloro-; 3-ChloroBCP-sulfonyl chloride; 3-Chloro-BCP-SO2Cl; 1-Chlorosulfonyl-3-chlorobicyclo[1.1.1]pentane
EINECS	Contact for details

Quality Control

Our 3-Chlorobicyclo[1.1.1]pentane-1-sulfonyl chloride is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.