Description

D-Erythro-N,n-Dimethylsphingosine is a high-purity, synthetic sphingolipid analog that serves as a potent and selective inhibitor of sphingosine kinase (SphK). This compound is a critical research tool for modulating the sphingosine-1-phosphate (S1P) signaling pathway, which plays a central role in cellular processes such as proliferation, apoptosis, and immune response regulation. It is essential for researchers and developers in pharmaceutical discovery, biochemistry, and cell biology who require reliable, high-quality chemical probes for target validation and mechanistic studies.

Application

• Biochemical Research: A key inhibitor for studying the role of sphingosine kinase 1 (SphK1) and the S1P pathway in cell signaling cascades.
• Pharmaceutical Development: Used as a reference standard and lead compound in the discovery of novel therapeutics targeting cancer, inflammation, and autoimmune diseases.
• Cell Biology Studies: Employed to investigate the effects of S1P pathway modulation on cell growth, differentiation, and programmed cell death (apoptosis).
• Academic Research: A fundamental tool in university and institutional labs for basic science research into lipid-mediated signaling.
• In-Vitro Diagnostics (IVD): May be utilized in the development of assay kits and reagents for research purposes.

Basic Information

Product Name	D-Erythro-N,n-Dimethylsphingosine
CAS No.	132031-17-5
Molecular Formula	C20H41NO2
Molecular Weight	327.55 g/mol
Synonyms	DMS; D-erythro-N,N-Dimethylsphingosine; (2S,3R)-2-Dimethylamino-3-hydroxyoctadec-4-ene; N,N-Dimethyl-D-erythro-sphingosine; N,N-Dimethylsphingosine; SKI-I; Sphingosine Kinase Inhibitor I; Sphingosine kinase inhibitor (DMS)
EINECS	Contact for details

Quality Control

Our D-Erythro-N,n-Dimethylsphingosine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.