Description

Mono-(6-(1,6-Hexamethylenediamine)-6-Deoxy)-β-Cyclodextrin is a chemically modified cyclodextrin derivative where a single primary amine group is introduced via a hexamethylenediamine spacer arm at the 6-position of the β-cyclodextrin ring. This functionalization is critical, as it transforms the native cyclodextrin into a versatile host molecule with enhanced binding capabilities and a reactive site for further conjugation. It is primarily utilized as a sophisticated molecular scaffold in pharmaceutical research, analytical chemistry, and material science. Industries requiring advanced chiral separation, targeted drug delivery systems, or novel sensor development are the key beneficiaries of this specialized reagent.

Application

• Pharmaceutical Research & Drug Delivery: Serves as a key building block for synthesizing targeted drug carriers, prodrugs, and gene delivery vectors due to its host-guest complexation ability and amine functionality for covalent linkage.
• Chiral Separation & Analysis: Used as a chiral selector or stationary phase modifier in High-Performance Liquid Chromatography (HPLC) and Capillary Electrophoresis (CE) for the enantiomeric resolution of pharmaceutical compounds.
• Chemical Sensor Development: Employed in the fabrication of biosensors and chemosensors, where its cavity can encapsulate specific analytes, and the amine group allows for immobilization onto transducer surfaces.
• Catalysis: Acts as a ligand or support for metal catalysts, facilitating reactions within its hydrophobic cavity to enhance selectivity and yield.
• Material Science: Incorporated into polymers, gels, and nanomaterials to impart molecular recognition properties or to create stimuli-responsive materials.
• Bioconjugation & Protein Modification: The primary amine group enables covalent coupling to proteins, antibodies, or other biomolecules for labeling, stabilization, or functionalization purposes.

Basic Information

Item	Details
Product Name	Mono-(6-(1,6-Hexamethylenediamine)-6-Deoxy)-β-Cyclodextrin
CAS No.	131991-61-2
Molecular Formula	C48H84N2O34
Molecular Weight	1209.18 g/mol
Synonyms	6A-Amino-6A-deoxy-β-cyclodextrin; 6-Monoamino-6-monodeoxy-β-cyclodextrin; 6A-Deoxy-6A-(6-aminohexyl)amino-β-cyclodextrin; Mono-6-deoxy-6-(6-aminohexyl)amino-β-cyclodextrin; 6I-Amino-6I-deoxy-β-cyclodextrin; Heptakis(6-deoxy-6-amino)-β-cyclodextrin (Note: This is the per-substituted analogue, often confused); β-CD-NH2 (hexyl); Amino-functionalized β-Cyclodextrin
EINECS	Contact for details

Quality Control

Our Mono-(6-(1,6-Hexamethylenediamine)-6-Deoxy)-β-Cyclodextrin is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and substitution degree analysis, NMR for structural confirmation, and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent absorption of moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Substitution Degree (NMR)	0.9 - 1.1
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.