Description

Carbovir-5'-o-Glucuronide is a key metabolite of the antiviral nucleoside analogue carbovir, formed via the glucuronidation pathway. This compound is of significant importance for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It serves as a critical reference standard for scientists and quality control laboratories in the pharmaceutical and biotechnology industries who require high-purity materials for accurate analytical testing.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantification and identification of carbovir metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the metabolic fate, clearance pathways, and bioavailability of carbovir and related antiviral compounds.
• Bioanalytical Method Development: Used to validate High-Performance Liquid Chromatography (HPLC) and Liquid Chromatography-Mass Spectrometry (LC-MS/MS) assays in support of preclinical and clinical trials.
• Impurity Profiling: Acts as a known impurity or degradation product standard to ensure the purity and stability of active pharmaceutical ingredients (APIs).
• Academic and Institutional Research: Supports fundamental virology and medicinal chemistry research focused on nucleoside analogues and their metabolic pathways.

Basic Information

Product Name	Carbovir-5'-o-Glucuronide
CAS No.	131956-47-3
Molecular Formula	C16H23N5O9
Molecular Weight	429.38 g/mol
Synonyms	Carbovir Glucuronide; (-)-Carbovir 5'-O-Glucuronide; 9-[(1R,4R)-4-(Hydroxymethyl)-2-cyclopenten-1-yl]guanine 5'-Glucuronide; 2-Amino-1,9-dihydro-9-[(1R,4R)-4-(hydroxymethyl)-2-cyclopenten-1-yl]-6H-purin-6-one 5'-Glucuronide; NSC 737064; Carbovir metabolite M2; BW1592U89 Glucuronide
EINECS	Contact for details

Quality Control

Our Carbovir-5'-o-Glucuronide is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods (NMR, MS) for structural confirmation, to ensure it meets the exacting standards required for research and reference materials. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and chromatographic data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and should be allowed to equilibrate to room temperature in a desiccator before opening to prevent condensation and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.