Description

1H-Indole-5-Sulfonyl Chloride, 2,3-Dihydro-3,3-Dimethyl-2- is a specialized sulfonyl chloride derivative of a dihydroindole scaffold. This compound serves as a critical high-purity synthetic building block for the development of novel active pharmaceutical ingredients (APIs) and advanced organic materials. It is primarily utilized by pharmaceutical R&D and fine chemical synthesis teams requiring a reactive intermediate for sulfonamide coupling reactions.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and other therapeutic areas.
• Sulfonamide Library Synthesis: Used in high-throughput and combinatorial chemistry to create diverse libraries of sulfonamide compounds for biological screening and structure-activity relationship (SAR) studies.
• Agrochemical Research: Employed in the development of new herbicides, fungicides, and insecticides where the sulfonamide functional group is essential for bioactivity.
• Material Science: Acts as a monomer or cross-linking agent in the synthesis of specialty polymers and advanced organic materials with specific functional properties.
• Chemical Biology Probes: Useful for the design and synthesis of chemical probes and affinity labels to study enzyme function and protein interactions.

Basic Information

Product Name	1H-Indole-5-Sulfonyl Chloride, 2,3-Dihydro-3,3-Dimethyl-2-
CAS No.	131880-56-3
Molecular Formula	C10H12ClNO2S
Molecular Weight	245.72 g/mol
Synonyms	2,3-Dihydro-3,3-dimethyl-1H-indole-5-sulfonyl chloride; 3,3-Dimethyl-2,3-dihydro-1H-indole-5-sulfonyl chloride; 5-(Chlorosulfonyl)-3,3-dimethyl-2,3-dihydro-1H-indole; 3,3-Dimethylindoline-5-sulfonyl chloride; 1H-Indole-5-sulfonyl chloride, 2,3-dihydro-3,3-dimethyl-
EINECS	Contact for details

Quality Control

Our 1H-Indole-5-Sulfonyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the stringent requirements of GMP and ISO standards for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.