Description

Ro-31-8425 is a potent and selective cell-permeable inhibitor of protein kinase C (PKC). This compound is a critical research tool for elucidating the role of PKC isoforms in cellular signaling pathways, disease mechanisms, and potential therapeutic interventions. It is primarily utilized by researchers and scientists in the fields of biochemistry, pharmacology, and oncology for in vitro and in vivo studies.

Application

• Biochemical Research: A key reagent for studying PKC-mediated signal transduction, enzyme kinetics, and substrate specificity.
• Pharmacological Studies: Used to investigate the role of PKC in disease models, including cancer, cardiovascular disorders, and neurological conditions.
• Cell Biology: Employed to modulate PKC activity in cell culture experiments to understand its effects on cell proliferation, differentiation, and apoptosis.
• Drug Discovery: Serves as a reference compound and a tool for validating assays in the development of novel PKC-targeted therapeutics.
• Academic & Industrial R&D: Essential for basic research in universities and applied research in pharmaceutical and biotechnology companies.

Basic Information

Product Name	Ro-31-8425
CAS No.	131848-97-0
Molecular Formula	C24H28N4O4
Molecular Weight	436.51 g/mol
Synonyms	3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione; Ro 31-8425; Ro318425; PKC Inhibitor Ro-31-8425; Bisindolylmaleimide IX; Protein Kinase C Inhibitor Ro-31-8425
EINECS	Contact for details

Quality Control

Our Ro-31-8425 is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant standards for research-grade biochemicals to guarantee reliable and reproducible experimental results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.