Description

2-Trifluoromethyl-4-Chloropyridine is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a chlorinated and a trifluoromethylated aromatic ring, makes it an indispensable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-infective drugs.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers and advanced electronic materials requiring specific fluorine-containing motifs.
• Custom Synthesis and Contract Manufacturing: A vital starting material for fine chemical manufacturers offering bespoke synthesis services to the life sciences sector.

Basic Information

Product Name	2-Trifluoromethyl-4-Chloropyridine
CAS No.	131748-14-6
Molecular Formula	C6H3ClF3N
Molecular Weight	181.54 g/mol
Synonyms	4-Chloro-2-(trifluoromethyl)pyridine; 2-(Trifluoromethyl)-4-chloropyridine; 4-Chloro-α,α,α-trifluoro-2-picoline; 4-Chloro-2-trifluoromethylpyridine; 2-Trifluoromethyl-4-chloropyridine; 4-Chloro-2-(trifluoromethyl)pyridine; 131748-14-6
EINECS	Contact for details

Quality Control

Our 2-Trifluoromethyl-4-Chloropyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, documenting all critical quality attributes. Our commitment to reliable supply and batch-to-batch consistency supports your stringent R&D and scale-up requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reactive metals. Due to the presence of fluoride, ensure containers are properly sealed and handled with appropriate precautions to avoid moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (by GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.