Description

4-Trifluoromethyl-Pyridine-2-Methanol is a high-value fluorinated pyridine derivative, a key building block in advanced organic synthesis. Its unique structure, featuring both a trifluoromethyl group and a hydroxymethyl substituent, makes it indispensable for modulating the physicochemical properties of target molecules. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials.
• Fluorine Chemistry Building Block: A versatile starting material for introducing the trifluoromethylpyridine moiety into complex molecular architectures.

Basic Information

Product Name	4-Trifluoromethyl-Pyridine-2-Methanol
CAS No.	131747-46-1
Molecular Formula	C7H6F3NO
Molecular Weight	177.12 g/mol
Synonyms	2-(Hydroxymethyl)-4-(trifluoromethyl)pyridine; (4-Trifluoromethyl-2-pyridinyl)methanol; 4-(Trifluoromethyl)pyridine-2-methanol; α-(4-Trifluoromethyl-2-pyridyl)methanol; 2-Pyridinemethanol, 4-(trifluoromethyl)-; 4-Trifluoromethyl-2-pyridinemethanol
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethyl-Pyridine-2-Methanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support development and commercial projects with material produced under current Good Manufacturing Practice (cGMP) guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.