Description

2-(Trifluoromethyl)Nicotinic Acid is a high-value trifluoromethylated pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its unique structure, combining a nicotinic acid core with a trifluoromethyl group, imparts desirable properties such as enhanced metabolic stability and lipophilicity to target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3 group improves biological activity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials requiring fluorinated aromatic components.
• Chemical Biology & Proteomics: Useful as a molecular probe or tag due to the distinctive spectroscopic signature of the trifluoromethyl group.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-(Trifluoromethyl)Nicotinic Acid
CAS No.	131747-43-8
Molecular Formula	C7H4F3NO2
Molecular Weight	191.11 g/mol
Synonyms	2-(Trifluoromethyl)pyridine-3-carboxylic acid; 3-Carboxy-2-(trifluoromethyl)pyridine; Nicotinic acid, 2-(trifluoromethyl)-; 2-Trifluoromethylnicotinic acid; 2-Carboxy-3-(trifluoromethyl)pyridine; 2-(Trifluoromethyl)-3-pyridinecarboxylic acid; 2-TFMNA
EINECS	Contact for details

Quality Control

Every batch of 2-(Trifluoromethyl)Nicotinic Acid is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and commercial synthesis. Our products undergo rigorous quality testing, including HPLC, NMR, and MS analysis, to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.