Description

2-Trifluoromethyl-6-Pyridinecarboxylic Acid is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique trifluoromethyl-substituted pyridine core offers enhanced lipophilicity and metabolic stability, making it indispensable for creating novel compounds with targeted properties. This intermediate is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors, anti-infectives, and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group can improve biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for constructing sophisticated ligands in catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of specialty polymers, liquid crystals, and electronic materials that benefit from fluorine incorporation.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Trifluoromethyl-6-Pyridinecarboxylic Acid
CAS No.	131747-42-7
Molecular Formula	C7H4F3NO2
Molecular Weight	191.11 g/mol
Synonyms	6-(Trifluoromethyl)pyridine-2-carboxylic acid; 2-Carboxy-6-(trifluoromethyl)pyridine; 6-(Trifluoromethyl)picolinic acid; 2-Pyridinecarboxylic acid, 6-(trifluoromethyl)-; α,α,α-Trifluoro-6-picolinic acid
EINECS	Contact for details

Quality Control

We supply 2-Trifluoromethyl-6-Pyridinecarboxylic Acid in high-purity grades suitable for research and commercial synthesis. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request. We adhere to strict internal quality management protocols to ensure batch-to-batch consistency and reliability for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.