Description

5-(Trifluoromethyl)Nicotinic Acid is a high-value fluorinated pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in the trifluoromethyl group, which imparts unique metabolic stability and lipophilicity to target molecules, enhancing their biological activity and drug-like properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), especially in kinase inhibitors and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the CF3 group improves efficacy and environmental profile.
• Ligand & Catalyst Development: Employed in the design of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Material Science: Acts as a precursor for functionalized polymers and liquid crystals with specific electronic or optical properties.
• Chemical Research: Serves as a versatile reagent in academic and industrial R&D for exploring new fluorination methodologies and heterocyclic chemistry.

Basic Information

Product Name	5-(Trifluoromethyl)Nicotinic Acid
CAS No.	131747-40-5
Molecular Formula	C7H4F3NO2
Molecular Weight	191.11 g/mol
Synonyms	3-Pyridinecarboxylic acid, 5-(trifluoromethyl)-; 5-(Trifluoromethyl)pyridine-3-carboxylic acid; Nicotinic acid, 5-(trifluoromethyl)-; 5-Trifluoromethylnicotinic acid; 5-Carboxy-3-(trifluoromethyl)pyridine; 3-Carboxy-5-(trifluoromethyl)pyridine
EINECS	Contact for details

Quality Control

Our 5-(Trifluoromethyl)Nicotinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product may be hygroscopic (moisture-sensitive); keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.