Description

Flavopiridol Hydrochloride is a potent and selective small-molecule inhibitor of cyclin-dependent kinases (CDKs), a key class of enzymes involved in cell cycle regulation. This compound is a critical research tool and a lead compound in oncology drug discovery, primarily valued for its ability to induce cell cycle arrest and apoptosis in various cancer cell lines. It is essential for pharmaceutical R&D, academic research in cell biology, and preclinical studies targeting hematologic malignancies and solid tumors.

Application

• Oncology Research & Drug Discovery: A key reference standard and pharmacological tool for studying CDK inhibition mechanisms and screening novel anti-cancer agents.
• Biochemical Assay Development: Used as a positive control in high-throughput screening (HTS) assays to validate CDK1, CDK2, CDK4, CDK6, and CDK9 activity assays.
• Cell Biology & Signal Transduction Studies: Employed to investigate cell cycle progression, transcription regulation, and programmed cell death (apoptosis) in vitro.
• Preclinical Cancer Models: Utilized in animal studies to evaluate the efficacy and pharmacokinetics of CDK inhibitor therapies.
• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in API manufacturing.
• Academic Research: Fundamental reagent for universities and research institutes exploring novel therapeutic pathways in cancer and other proliferative diseases.

Basic Information

Item	Details
Product Name	Flavopiridol Hydrochloride
CAS No.	131740-09-5
Molecular Formula	C21H20ClNO5 • HCl
Molecular Weight	438.30 g/mol (for hydrochloride salt)
Synonyms	Alvocidib Hydrochloride; HMR 1275 Hydrochloride; L86-8275; Flavopiridol HCl; (-)-cis-5,7-Dihydroxy-2-(2-chlorophenyl)-8-[4-(3-hydroxy-1-methyl)piperidinyl]-4H-1-benzopyran-4-one hydrochloride; CDK Inhibitor II; NSC 649890
EINECS	Contact for details

Quality Control

Our Flavopiridol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and heavy metals. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. The product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm
Assay (Titration)	97.0% - 103.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.