Description

Amoa Non-NMDA Glutamate Re CAS NO 131417-68-0 is a potent and selective agonist for the AMPA subtype of ionotropic glutamate receptors, a key target in neuroscience research. This compound is essential for studying excitatory synaptic transmission, neuronal plasticity, and the mechanisms underlying various neurological disorders. It is primarily utilized by pharmaceutical researchers, academic neuroscientists, and R&D departments in biotechnology firms focused on CNS drug discovery and neuropharmacology.

Application

• Neuroscience Research: A critical tool for electrophysiological studies to characterize AMPA receptor function and kinetics.
• Drug Discovery & Screening: Used in high-throughput assays to identify and validate novel AMPA receptor modulators, antagonists, or allosteric regulators for therapeutic development.
• Neuropharmacology Studies: Investigating the role of glutamatergic signaling in conditions such as epilepsy, stroke, neurodegenerative diseases (e.g., Alzheimer's, ALS), and chronic pain.
• Cellular & Molecular Biology: Probing receptor trafficking, synaptic plasticity mechanisms like LTP/LTD, and excitotoxicity pathways in neuronal cell cultures.
• Biochemical Assay Development: Serving as a reference standard in binding assays, fluorescence-based assays, and other in vitro test systems targeting the AMPA receptor.

Basic Information

Product Name	Amoa Non-NMDA Glutamate Re
CAS No.	131417-68-0
Molecular Formula	C7H10N2O5S
Molecular Weight	234.23 g/mol
Synonyms	AMOA; (RS)-2-Amino-3-[3-(carboxymethoxy)-5-methylisoxazol-4-yl]propionic acid; (RS)-AMOA; AMPA receptor antagonist AMOA; 4-[[(2S)-2-Amino-2-carboxyethyl]methoxy]-5-methyl-3-isoxazoleacetic acid; LY 300168; AMOA, non-NMDA glutamate receptor antagonist
EINECS	Contact for details

Quality Control

Our Amoa Non-NMDA Glutamate Re is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) documenting identity, purity, and assay results is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment. For long-term stability, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.