Description

7-Methyl-10-Bromoacetamidomethylcamptothecin CAS NO 131206-46-7 is a high-purity, synthetic camptothecin derivative, a class of compounds renowned for their potent topoisomerase I inhibitory activity. This compound serves as a critical advanced pharmaceutical intermediate for the research and development of novel anticancer therapeutics. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of targeted oncology drugs and prodrugs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of next-generation camptothecin-based anticancer agents and prodrugs.
• Oncology Research: Used as a reference standard and active compound in biochemical assays to study topoisomerase I inhibition mechanisms.
• Drug Discovery: Serves as a core scaffold for medicinal chemistry programs aimed at improving the solubility, stability, and tumor-targeting efficacy of camptothecin derivatives.
• Preclinical Development: Employed in the formulation and efficacy testing of experimental chemotherapeutic candidates in vitro and in vivo.
• Bioconjugation Studies: The bromoacetamidomethyl moiety provides a reactive handle for conjugation with antibodies, peptides, or polymers to create targeted drug delivery systems.
• Academic Research: Utilized in university and institutional labs for fundamental studies on cell cycle arrest and apoptosis induction in cancer cell lines.

Basic Information

Product Name	7-Methyl-10-Bromoacetamidomethylcamptothecin
CAS No.	131206-46-7
Molecular Formula	C24H22BrN3O5
Molecular Weight	512.36 g/mol
Synonyms	10-Bromoacetamidomethyl-7-methylcamptothecin; 7-Methyl-10-[(bromoacetyl)amino]methylcamptothecin; 10-[(Bromoacetyl)amino]methyl-7-methylcamptothecin; Camptothecin, 10-[[(bromoacetyl)amino]methyl]-7-methyl-; 7-Methylcamptothecin 10-(bromoacetamidomethyl) ether (obsolete); BAMC; 7-Methyl-BAMC; 10-BAMC-7-Me-CPT
EINECS	Contact for details

Quality Control

Our 7-Methyl-10-Bromoacetamidomethylcamptothecin is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and pharmaceutical development. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support development projects requiring material that aligns with ICH guidelines for impurities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.