Description

10-Bromoacetamidomethylcamptothecin is a potent, semi-synthetic derivative of the natural alkaloid camptothecin, specifically functionalized with a reactive bromoacetamidomethyl group. This modification is critical for its primary role as a key intermediate in the synthesis of advanced antibody-drug conjugates (ADCs) and targeted cancer therapeutics. It is essential for pharmaceutical R&D and manufacturing teams focused on developing next-generation oncology treatments, particularly those utilizing linker-payload technologies for precise tumor targeting.

Application

• Primary Intermediate for ADC Payloads: Serves as a crucial building block for constructing cytotoxic payloads in antibody-drug conjugates (ADCs).
• Targeted Cancer Therapy Research: Used in the development and synthesis of novel chemotherapeutic agents designed for selective tumor cell delivery.
• Topoisomerase I Inhibitor Prodrugs: A precursor for prodrugs that are activated to inhibit topoisomerase I, a key enzyme in DNA replication.
• Bioconjugation and Linker Chemistry: The reactive bromoacetamide group enables site-specific conjugation to antibodies, peptides, or other targeting moieties via thiol or amine groups.
• Preclinical and Clinical-Stage Pharmaceutical Development: Employed in the synthesis of compounds for efficacy and toxicity studies.
• Chemical Biology Probes: Utilized to create tool compounds for studying drug mechanism of action and cellular uptake pathways.

Basic Information

Product Name	10-Bromoacetamidomethylcamptothecin
CAS No.	131206-45-6
Molecular Formula	C23H20BrN3O5
Molecular Weight	498.33 g/mol
Synonyms	10-Bromoacetamidomethylcamptothecin; 10-[(Bromoacetyl)amino]methylcamptothecin; Camptothecin, 10-[[(bromoacetyl)amino]methyl]-; ADC Linker-Payload Intermediate; Bromoacetamidomethyl-CPT; CPT-BAM
EINECS	Contact for details

Quality Control

Our 10-Bromoacetamidomethylcamptothecin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, essential for sensitive pharmaceutical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques including HPLC, NMR, and MS. We adhere to cGMP guidelines for the production of pharmaceutical intermediates, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.