Description

Hirullin CAS NO 131147-81-4 is a potent and selective direct thrombin inhibitor, a synthetic peptide derived from the salivary secretions of the medicinal leech *Hirudo medicinalis*. This compound is critical for research and development in the life sciences, particularly in the study of blood coagulation pathways and thrombosis. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic manufacturers working on novel anticoagulant therapies, diagnostic assays, and biochemical studies.

Application

• Biochemical Research: As a specific inhibitor of thrombin for studying coagulation cascades, enzyme kinetics, and protease function in vitro.
• Pharmaceutical Development: A key reference standard and tool compound in the discovery and screening of new antithrombotic and anticoagulant drug candidates.
• Diagnostic Reagents: Used in the formulation of specialized diagnostic kits and assays for measuring thrombin activity or for quality control in hemostasis testing.
• Cell Biology Studies: Employed to inhibit thrombin-mediated cellular responses, such as platelet activation or signaling in endothelial and smooth muscle cells.
• Structural Biology: Serves as a ligand for X-ray crystallography and other techniques to study thrombin-inhibitor complex structures.

Basic Information

Product Name	Hirullin
CAS No.	131147-81-4
Molecular Formula	C82H126N24O21
Molecular Weight	1799.06 g/mol
Synonyms	Hirullin; Hirullin peptide; D-Phe-Pro-Arg-Hirudin(55-65); Thrombin inhibitor Hirullin; H-D-Phe-Pro-Arg-Pro-(Gly)4-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu-OH; (D-Phe)-Pro-Arg-Pro-(Gly)4-Asn-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr-Leu; Hirullin P18
EINECS	Contact for details

Quality Control

Our Hirullin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided, documenting purity, peptide content, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.