Description

20,20,20-Trifluoroleukotriene E4 is a fluorinated analog of the potent inflammatory mediator leukotriene E4, distinguished by the substitution of three hydrogen atoms with fluorine at the 20-position. This structural modification is critical for enhancing metabolic stability and receptor binding affinity in advanced pharmacological research. This high-purity biochemical is essential for researchers and developers in the pharmaceutical and biotechnology sectors, particularly those focused on respiratory and inflammatory disease pathways, drug discovery, and the development of novel leukotriene receptor antagonists.

Application

• Pharmacological Reference Standard: Serves as a critical certified standard for the quantification and identification of leukotriene pathways in bioanalytical assays.
• Drug Discovery & Development: Used as a key intermediate or target molecule in the synthesis and screening of new anti-inflammatory and respiratory therapeutics.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate the role of cysteinyl leukotrienes in asthma, allergies, and other inflammatory conditions.
• Mechanism of Action Studies: Facilitates research into receptor-ligand interactions and signal transduction mechanisms of the CysLT1 receptor.
• Metabolic Stability Assays: The fluorinated structure makes it a valuable tool for studying drug metabolism and pharmacokinetics (DMPK) related to eicosanoid analogs.

Basic Information

Product Name	20,20,20-Trifluoroleukotriene E4
CAS No.	131074-64-1
Molecular Formula	C23H32F3NO5S
Molecular Weight	503.56 g/mol
Synonyms	(5S,6R)-7-[(1R,2E,4E,6Z,9Z)-1-[(2S)-2-Amino-2-carboxyethyl]sulfanyl-2,4,6,9-heptadecatetraen-1-ylidene]-5,6-epoxy-20,20,20-trifluoroicosa-8,10,14-trienoic acid; 20,20,20-Trifluoro-LTE4; Fluoroleukotriene E4; 20-Trifluoromethylleukotriene E4; LTE4 fluorinated analog; 20,20,20-Trifluoro-5(S)-hydroxy-6(R)-S-cysteinylglycyl-7,9-trans-11,14-cis-eicosatetraenoic acid
EINECS	Contact for details

Quality Control

Our 20,20,20-Trifluoroleukotriene E4 is manufactured under strict quality control protocols to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles for the production of advanced pharmaceutical intermediates, and our quality system supports compliance with global regulatory requirements for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere (e.g., argon or nitrogen) after each use to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.