Description

5,11-Methylenetetrahydro-5-Deazahomofolic Acid is a specialized folate analog and key chemical intermediate of significant interest in advanced pharmaceutical research and development. This compound matters for its role as a precursor in the synthesis of novel antifolate agents and enzyme inhibitors, offering a pathway to targeted therapeutic molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in oncology drug discovery, metabolic pathway studies, and the development of enzyme-targeted treatments.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel antifolate drugs and enzyme inhibitors for therapeutic applications.
• Oncology Research: Used in the development and study of compounds targeting folate-dependent enzymes in cancer cell proliferation.
• Biochemical Research: Serves as a reference standard and tool compound in enzymatic studies, particularly for dihydrofolate reductase (DHFR) and thymidylate synthase.
• Metabolic Pathway Analysis: Employed in research to investigate and modulate one-carbon metabolism and nucleotide biosynthesis pathways.
• Academic & Contract Research: Utilized in university laboratories and CROs (Contract Research Organizations) for exploratory medicinal chemistry projects.

Basic Information

Product Name	5,11-Methylenetetrahydro-5-Deazahomofolic Acid
CAS No.	130985-82-9
Molecular Formula	C21H25N7O5
Molecular Weight	455.47 g/mol
Synonyms	5,11-Methylene-5,6,7,8-tetrahydro-5-deazahomofolic Acid; 5-Deaza-5,11-methylenetetrahydrohomofolate; NSC 380292; 5,11-CH2-H4-5-deazahomofolate; 5,11-Methylenetetrahydrohomofolate analog; 5-Deazaaminopterin analog; Tetrahydro-5-deazahomofolic acid, 5,11-methylene-
EINECS	Contact for details

Quality Control

Our 5,11-Methylenetetrahydro-5-Deazahomofolic Acid is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.