Description

Acetylphenylalanyl-Prolyl-Boroarginine is a synthetic peptide boronic acid derivative, a potent and selective inhibitor of thrombin and other serine proteases. Its core value proposition lies in its high specificity and efficacy as a research tool for studying coagulation pathways and protease activity. This compound is primarily needed by researchers in the pharmaceutical and biotechnology sectors for drug discovery, biochemical assay development, and as a reference standard. The product is supplied under strict quality control to ensure reliable and reproducible results for critical research applications.

Application

• Biochemical Research: Used as a potent, selective inhibitor in enzymatic studies to investigate the mechanism of thrombin and related serine proteases.
• Pharmaceutical Development: Serves as a key reference compound and pharmacophore model in the discovery and optimization of novel anticoagulant and anti-thrombotic drugs.
• Diagnostic Reagent Component: Employed in the development of in-vitro diagnostic assays and kits for measuring coagulation parameters and protease activity.
• Cell Biology Studies: Utilized to modulate protease-dependent signaling pathways in cellular models to study their role in physiology and disease.
• Proteomics: Acts as an affinity ligand or activity-based probe for the isolation, identification, and profiling of specific protease families.

Basic Information

Product Name	Acetylphenylalanyl-Prolyl-Boroarginine
CAS No.	130982-43-3
Molecular Formula	C23H34BN7O6
Molecular Weight	515.18 g/mol
Synonyms	Ac-Phe-Pro-boroArg; Bortezomib Intermediate; Thrombin Inhibitor I; Acetyl-Phe-Pro-boroArg-OH; (R)-1-((S)-2-Acetamido-3-phenylpropanoyl)-N-((S)-1-((3aS,4S,6S,7aR)-3a,5,5-trimethylhexahydro-4,6-methanobenzo[d][1,3,2]dioxaborol-2-yl)-4-guanidinobutyl)pyrrolidine-2-carboxamide; L-Phenylalanine, N-acetyl-, (2S)-1-[[(1S)-1-[[(3aS,4S,6S,7aR)-hexahydro-3a,5,5-trimethyl-4,6-methano-1,3,2-benzodioxaborol-2-yl]amino]-4-guanidinobutyl]-L-prolyl]-; Boro-Arg derivative
EINECS	Contact for details

Quality Control

Our Acetylphenylalanyl-Prolyl-Boroarginine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Quality is verified by multiple orthogonal methods including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each batch to support your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.