Description

n-[2-(p-Cinnamylamino)Ethyl]-5-Isoquinolone Sulfonamide is a specialized organic compound belonging to the class of isoquinolone sulfonamides, which are recognized for their role as potent and selective enzyme inhibitors in biochemical research. This compound is of significant value in the pharmaceutical and life science sectors for its utility as a key intermediate or reference standard in drug discovery and development programs. It is primarily sought by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in developing novel therapeutic agents, particularly those targeting specific kinase or protease pathways.

Application

• Pharmaceutical Research Intermediate: Serves as a critical building block in the synthesis of novel drug candidates, particularly for oncology and neurological disorders.
• Biochemical Probe Development: Used as a reference standard or starting material for creating selective enzyme inhibitors to study cellular signaling pathways.
• Kinase Inhibitor Research: Acts as a core scaffold or precursor in the development of potent and selective kinase inhibitors for targeted therapies.
• Academic & Contract Research: Employed in university and CRO laboratories for fundamental research in medicinal chemistry and pharmacology.
• High-Purity Reference Standard: Supplied as a certified reference material (CRM) for analytical method development, validation, and quality control in API manufacturing.

Basic Information

Product Name	n-[2-(p-Cinnamylamino)Ethyl]-5-Isoquinolone Sulfonamide
CAS No.	130964-40-8
Molecular Formula	C20H21N3O2S
Molecular Weight	367.47 g/mol
Synonyms	5-Isoquinolinesulfonamide, N-[2-[[(2E)-3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]amino]ethyl]-; N-[2-[(E)-Cinnamylamino]ethyl]-5-isoquinolinesulfonamide; H-89 Dihydrochloride (related analog); Protein Kinase A Inhibitor H-89 (precursor); 1,5-Isoquinolinediol, 8-(aminosulfonyl)-, derivative; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our n-[2-(p-Cinnamylamino)Ethyl]-5-Isoquinolone Sulfonamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom synthesis and purification to meet specific pharmacopeial or client-defined standards (e.g., >98% HPLC purity) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccant use and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	< 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.