Description

Phenylalanyl-Prolyl-Boroarginine is a synthetic, peptide-based boronic acid derivative designed as a potent and selective inhibitor of thrombin. This compound matters for its critical role in advanced biochemical research and development, particularly in the study of serine protease mechanisms and anticoagulant pathways. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and diagnostic manufacturers focused on developing novel therapeutics and analytical assays for hemostasis and thrombosis.

Application

• Biochemical Research: Used as a high-affinity, reversible inhibitor in mechanistic studies of thrombin and related serine proteases.
• Pharmaceutical Development: Serves as a key reference standard and pharmacophore model in the discovery of new anticoagulant and antithrombotic drug candidates.
• Diagnostic Assays: Employed in the development and calibration of in-vitro diagnostic (IVD) kits for monitoring blood coagulation parameters.
• Enzyme Kinetics: A valuable tool for studying enzyme inhibition kinetics, binding affinity, and transition-state analog interactions.
• Proteomics: Used in activity-based protein profiling (ABPP) to identify and characterize active serine proteases in complex biological samples.

Basic Information

Product Name	Phenylalanyl-Prolyl-Boroarginine
CAS No.	130926-95-3
Molecular Formula	C23H36BN7O5
Molecular Weight	501.19 g/mol
Synonyms	Phe-Pro-BoroArg; Boroarginine Peptide Inhibitor; Thrombin Inhibitor, Peptide Boronic Acid; Ac-(D)Phe-Pro-boroArg-OH; L-Phenylalanyl-N-[(1S)-4-[(diaminomethylidene)amino]-1-(dihydroxyboranyl)butyl]-L-prolinamide; DU-22b; DU 22b
EINECS	Contact for details

Quality Control

Our Phenylalanyl-Prolyl-Boroarginine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and specific tests for residual solvents and heavy metals. Certificates of Analysis (COA) with full traceability are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.