Description

6-o-Desmethyl Buprenorphine is a key pharmaceutical intermediate and metabolite of the opioid partial agonist buprenorphine. This compound is of critical importance for analytical and research purposes, particularly in the fields of forensic toxicology, clinical pharmacology, and drug development. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and manufacturers of reference standards and diagnostic kits for method development, calibration, and quality control.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantitative and qualitative analysis of buprenorphine and its metabolites in biological matrices.
• Forensic Toxicology: Essential for developing and validating LC-MS/MS, GC-MS, and HPLC methods used in workplace drug testing, post-mortem analysis, and driving under the influence of drugs (DUID) cases.
• Clinical Research & Pharmacokinetics: Used in studies to understand the metabolic pathways, bioavailability, and elimination profiles of buprenorphine in patients undergoing treatment for opioid use disorder or pain management.
• Drug Development & Impurity Profiling: Employed as a process-related impurity or degradation product standard to ensure the safety, purity, and quality of buprenorphine-based pharmaceutical formulations.
• Diagnostic Kit Manufacturing: A critical component in the production of immunoassay kits and other in-vitro diagnostic (IVD) devices designed for drug screening.

Basic Information

Product Name	6-o-Desmethyl Buprenorphine
CAS No.	130668-48-3
Molecular Formula	C₂₈H₃₇NO₄
Molecular Weight	451.60 g/mol
Synonyms	Nor-Buprenorphine; 6-Desmethylbuprenorphine; 6-O-Desmethylbuprenorphine; Buprenorphine Impurity C; Buprenorphine Metabolite; 21-Cyclopropyl-7-[(5R,6R)-6-hydroxy-6-(hydroxymethyl)-3-methyloct-1-en-6-yl]-3-methoxy-17-methyl-6,14-ethenomorphinan-3-ol; 17-(Cyclopropylmethyl)-6,7,8,14-tetrahydro-7-(1-hydroxy-1-methyl-3-phenylpropyl)-6-methoxy-4,5-epoxy-3-methoxymorphinan
EINECS	Contact for details

Quality Control

Our 6-o-Desmethyl Buprenorphine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identity confirmation by spectroscopic methods (NMR, IR, MS) and purity assessment by validated chromatographic methods (HPLC, GC). We provide Certificates of Analysis (COA) detailing batch-specific results for identity, assay, purity, and related substances, ensuring traceability and compliance with research and pharmaceutical industry standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Keep the container in a dry, cool, and well-ventilated area. For long-term storage, consider storing under inert atmosphere at lower temperatures (-20°C) to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%
Assay (HPLC)	97.0% - 103.0% (on anhydrous basis)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.