Description

Bindarit is a small molecule pharmaceutical intermediate and research chemical with specific biological activity. This compound is valued for its role as a selective inhibitor of monocyte chemotactic protein-1 (MCP-1/CCL2) synthesis, making it a critical tool in immunological and inflammatory research. It is primarily utilized by pharmaceutical R&D departments, biotechnology companies, and academic research institutions investigating pathways related to autoimmune diseases, atherosclerosis, and cancer metastasis.

Application

• Pharmaceutical Intermediate: Key starting material or building block in the synthesis of novel therapeutic agents targeting inflammatory pathways.
• Biochemical Research: Used as a selective inhibitor to study the role of MCP-1 in various disease models, including rheumatoid arthritis, lupus, and multiple sclerosis.
• Preclinical Development: Employed in animal studies to validate anti-inflammatory targets and assess the efficacy of new treatment modalities.
• Cell Biology Studies: Applied in in vitro assays to investigate monocyte and macrophage migration, activation, and related signaling cascades.
• Academic Research: A standard reagent in university and institutional labs for fundamental research into chemokine biology and immunology.

Basic Information

Product Name	Bindarit
CAS No.	130641-38-2
Molecular Formula	C₁₉H₂₀N₂O₃
Molecular Weight	324.38 g/mol
Synonyms	2-[(1-Benzyl-1H-indazol-3-yl)methoxy]-2-methylpropanoic acid; AF 2838; Bindarit (AF2838); 2-Methyl-2-[[1-(phenylmethyl)-1H-indazol-3-yl]methoxy]propanoic acid; 1-Benzyl-1H-indazole-3-carboxylic acid, 2-methyl-2-(methyloxy)propyl ester (related form); MCP-1 Synthesis Inhibitor
EINECS	Contact for details

Quality Control

Our Bindarit is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with relevant guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.