Description

Homoisocarbacyclin is a stable synthetic analog of prostacyclin (PGI2), a potent vasodilator and inhibitor of platelet aggregation. This compound is valued for its enhanced chemical stability compared to natural prostacyclin, making it a crucial tool for cardiovascular and pharmacological research. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on developing novel therapeutics for hypertension, pulmonary arterial hypertension (PAH), and thrombosis.

Application

• Cardiovascular Research: Used as a reference standard and active agent in studies investigating vasodilation, platelet aggregation inhibition, and vascular remodeling.
• Drug Discovery & Development: Serves as a key intermediate or lead compound in the synthesis of novel prostacyclin receptor (IP receptor) agonists for treating pulmonary arterial hypertension (PAH).
• Biochemical Assays: Employed in in vitro and cell-based assays to study IP receptor signaling pathways, cAMP elevation, and smooth muscle cell relaxation.
• Pharmacology Studies: Utilized in preclinical models to evaluate hemodynamic effects, organ protection, and anti-inflammatory properties.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in pharmaceutical analysis (HPLC, LC-MS).

Basic Information

Product Name	Homoisocarbacyclin
CAS No.	130377-59-2
Molecular Formula	C₂₂H₃₄O₄
Molecular Weight	362.5 g/mol
Synonyms	9(0)-Methano-δ6(9α)-PGI1; 15-Cyclopentyl-ω-pentanor-5(E)-carbaprostacyclin; Carbacyclin analog; TEI-9063; 15-Cyclopentyl-16,17,18,19,20-pentanor-5(E)-carbaprostacyclin; (5Z)-7-[(1R,2R,3R,5S)-3-[(1E,3S)-3-Cyclopentyl-3-hydroxy-1-propen-1-yl]-2,5-dihydroxycyclopentyl]-5-heptenoic Acid
EINECS	Contact for details

Quality Control

Our Homoisocarbacyclin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis to ensure it meets high-grade research standards. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-controlled environment. The product is hygroscopic and light-sensitive; allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.