Description

5-Deazaisofolic Acid is a high-purity, specialized heterocyclic compound of significant interest in advanced pharmaceutical research and development. This compound serves as a critical synthetic intermediate and a structural analog for the design and study of novel enzyme inhibitors, particularly in the fields of oncology and metabolic disease. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the synthesis of targeted therapeutic agents and biochemical probes.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel antifolate and anticancer drug candidates.
• Biochemical Research: Used as a reference standard or probe in enzymatic studies targeting folate-dependent pathways.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Academic Research: Employed in universities and research institutes for investigating cellular metabolism and nucleotide biosynthesis.
• Fine Chemical Synthesis: Intermediate for producing more complex, high-value specialty chemicals with biological activity.

Basic Information

Product Name	5-Deazaisofolic Acid
CAS No.	130327-67-2
Molecular Formula	C20H21N7O5
Molecular Weight	439.43 g/mol
Synonyms	5-Deaza-iso-folic acid; 5-Deaza-isofolate; 2-[[4-[[(2-Amino-5,6,7,8-tetrahydro-4-oxopyrido[2,3-d]pyrimidin-6-yl)methyl]amino]benzoyl]amino]pentanedioic acid; NSC 113927; 5-Deazaaminopterin analog; Isofolic acid deaza derivative
EINECS	Contact for details

Quality Control

Our 5-Deazaisofolic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is subjected to comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.