Description

5-(Difluoromethoxy)-2-Fluoropyridine is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique difluoromethoxy and fluorine substituents make it an essential intermediate for introducing specific physicochemical properties into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) drugs and kinase inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorinated structure enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and electronic materials.
• Chemical Research & Development: A versatile reagent in medicinal chemistry and process chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Fluorine Chemistry: Valuable synthon for introducing the difluoromethoxy group into complex molecules, a motif known to improve metabolic stability and membrane permeability.

Basic Information

Product Name	5-(Difluoromethoxy)-2-Fluoropyridine
CAS No.	130318-80-8
Molecular Formula	C6H4F3NO
Molecular Weight	163.10 g/mol
Synonyms	2-Fluoro-5-(difluoromethoxy)pyridine; 5-(Difluoromethoxy)-2-fluoropyridine; 2-Fluoropyridine-5-difluoromethyl ether; 130318-80-8; Pyridine, 5-(difluoromethoxy)-2-fluoro-; 2-Fluoro-5-difluoromethoxypyridine
EINECS	Contact for details

Quality Control

Our 5-(Difluoromethoxy)-2-Fluoropyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.