Description

Cetrorelix Trifluoroacetate is a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH) that acts as a potent antagonist. This compound is critical for the controlled inhibition of gonadotropin secretion in therapeutic and research settings. It is primarily utilized by pharmaceutical manufacturers and advanced research institutions in the development and production of treatments for hormone-dependent conditions, such as in assisted reproductive technologies and oncology.

Application

• Pharmaceutical Active Ingredient (API): Core component in injectable formulations for fertility control and the treatment of hormone-sensitive disorders.
• Assisted Reproductive Technology (ART): Used to prevent premature luteinizing hormone (LH) surges during ovarian stimulation protocols like in vitro fertilization (IVF).
• Endocrinology Research: A vital tool for studying GnRH receptor mechanisms, pituitary gland function, and hormonal feedback loops in preclinical models.
• Oncology Research: Investigated for potential applications in managing cancers that are stimulated by sex hormones, such as prostate and breast cancer.
• Reference Standard: Serves as a high-purity analytical standard for quality control testing in pharmaceutical laboratories.
• Peptide Chemistry & Process Development: Used as a model compound in the development and optimization of peptide synthesis, purification, and scale-up processes.

Basic Information

Product Name	Cetrorelix Trifluoroacetate
CAS No.	130289-71-3
Molecular Formula	C₇₀H₉₂ClN₁₇O₁₄ • C₂HF₃O₂
Molecular Weight	~1431.0 g/mol (as trifluoroacetate salt)
Synonyms	Cetrorelix Acetate; Cetrotide (brand name); Ac-D-Nal-D-Cpa-D-Pal-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala-NH₂ • CF₃COOH; (Ac-D-2Nal1-D-4Cpa2-D-3Pal3-Ser4-Tyr5-D-Cit6-Leu7-Arg8-Pro9-D-Ala10)NH₂ trifluoroacetate; GnRH Antagonist (Cetrorelix); Gonadorelin (5-D-2Nal-4Cl-D-Phe-3-Pal-Ser-Tyr-D-Cit-Leu-Arg-Pro-D-Ala) Acetate; Cetrorelix TFA Salt
EINECS	Contact for details

Quality Control

Our Cetrorelix Trifluoroacetate is manufactured under strict quality systems suitable for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting specifications. Certificates of Analysis (COA) with full traceability are provided, supporting compliance with cGMP and ICH Q7 guidelines for active pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Purity (HPLC, Total Related Substances)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH Q3C limits
Trifluoroacetate Content (Titration)	5.0% - 12.0%
Bacterial Endotoxins	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.