Description

Duocarmycin Sa CAS NO 130288-24-3 is a potent, naturally occurring antitumor antibiotic belonging to the cyclopropapyrroloindole (CPI) family. Its significance lies in its unique mechanism of action, which involves sequence-selective alkylation of DNA, making it a highly valuable compound for advanced pharmaceutical research and development. This product is essential for researchers and developers in the oncology and medicinal chemistry sectors, particularly those focused on creating novel antibody-drug conjugates (ADCs) and targeted cancer therapies.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as a highly potent warhead in the development of next-generation ADCs for targeted cancer treatment.
• Oncology Research: Used as a reference standard and active pharmaceutical ingredient (API) in preclinical studies to investigate DNA alkylation and cytotoxic mechanisms.
• Medicinal Chemistry: A key intermediate and model compound for the synthesis and structure-activity relationship (SAR) studies of novel CPI analogs.
• Biochemical Research: Employed in studies of DNA-interactive agents and their effects on cellular processes like transcription and replication.
• Pharmaceutical Development: Utilized in the formulation and stability testing of potent cytotoxic drug candidates.

Basic Information

Product Name	Duocarmycin Sa
CAS No.	130288-24-3
Molecular Formula	C31H40N4O8
Molecular Weight	620.67 g/mol
Synonyms	Duocarmycin SA; CC-1065 analog; (1R,2S,8S,8aR)-1,2,8-Trihydroxy-5-[[(2S)-2-hydroxy-2-[(1S,5S,6S)-5-hydroxy-6-[(2S)-1-[(2S)-2-[(1-methoxycarbonylpropyl)amino]-1-oxopropan-2-yl]pyrrolidin-2-yl]-7-methyl-3-oxo-1,2-dihydrocyclopropa[b]indol-4-yl]ethyl]-6-methyl-3-oxo-2,3,5,6,7,8-hexahydro-1H-cyclopropa[b]indol-4-yl] 3-methylbut-2-enoate; (+)-Duocarmycin SA; DUOCA-SA
EINECS	Contact for details

Quality Control

Our Duocarmycin Sa is manufactured under strict quality management systems to ensure the highest standards of purity and consistency, suitable for research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry guidelines to support our global clientele in pharmaceutical and biotech sectors.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. Due to its hygroscopic (moisture-sensitive) nature, the container must be sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.