Description

27-Methyl 7-o-(4-Azidobenzoyl)Okadaate is a chemically modified derivative of the potent phosphatase inhibitor okadaic acid, designed for advanced biochemical research. This compound is a critical tool for studying cellular signaling pathways, particularly protein phosphatase 1 (PP1) and 2A (PP2A) inhibition, with its azido group enabling photoaffinity labeling and cross-linking studies. It is primarily utilized by research scientists and pharmaceutical developers in the fields of molecular biology, oncology, and neurobiology for probing disease mechanisms and drug discovery.

Application

• Biochemical Research Probe: A key reagent for investigating the specific roles of serine/threonine protein phosphatases PP1 and PP2A in cellular processes.
• Photoaffinity Labeling: The incorporated azido benzoyl group allows for UV-induced cross-linking to target proteins, facilitating the identification and isolation of phosphatase complexes.
• Signal Transduction Studies: Used to induce hyperphosphorylation of cellular proteins by inhibiting dephosphorylation, helping to map phosphorylation-dependent signaling networks.
• Cancer Research: Employed in studies of tumor promotion and cell cycle regulation, as okadaic acid derivatives are known tumor promoters.
• Neurodegenerative Disease Models: Applied in research models to study tau protein hyperphosphorylation, relevant to Alzheimer's disease and related tauopathies.
• Tool Compound Development: Serves as a precursor or reference standard in the development of novel, more selective phosphatase inhibitors for therapeutic applications.

Basic Information

Product Name	27-Methyl 7-o-(4-Azidobenzoyl)Okadaate
CAS No.	130288-23-2
Molecular Formula	C46H65NO10
Molecular Weight	815.99 g/mol
Synonyms	7-O-(4-Azidobenzoyl)-27-methylokadaate; 27-Methyl-7-O-(4-azidobenzoyl)okadaic Acid; 7-O-(p-Azidobenzoyl)-27-methylokadaate; Okadaic Acid, 27-methyl-7-O-(4-azidobenzoyl)- derivative; Azidobenzoyl Methyl Okadaate; PP1/PP2A Photoaffinity Probe; CAS 130288-23-2
EINECS	Contact for details

Quality Control

Our 27-Methyl 7-o-(4-Azidobenzoyl)Okadaate is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This compound is light-sensitive (store away from light) and should be handled under inert atmosphere when possible to maintain stability. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in alcohols

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.