Description

4,5,18,18,19,19-Hexadehydro-16,20-Dimethyl-Delta 6(9A)-9(O)-Methano-Pr Ostaglandin I1 CAS NO 130273-99-3 is a synthetic prostaglandin I1 (PGI1) analogue, a complex organic compound belonging to the prostanoid class. This compound is of significant interest for its potential as a key intermediate or reference standard in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies focused on cardiovascular, pulmonary, and anti-thrombotic therapeutics, where the study of prostacyclin pathways is critical.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel prostacyclin (PGI2) analogue drugs.
• Biochemical Research: Used as a reference standard or probe in studies investigating prostanoid receptor (IP receptor) binding, signaling, and function.
• Cardiovascular Drug Discovery: Applied in R&D programs targeting vasodilation, inhibition of platelet aggregation, and cytoprotection.
• Pulmonary Hypertension Research: Investigated for potential applications in developing treatments for pulmonary arterial hypertension (PAH).
• Analytical Standard: Employed in analytical laboratories for method development and validation using techniques like HPLC and LC-MS.
• Medicinal Chemistry: Provides a complex scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.

Basic Information

Product Name	4,5,18,18,19,19-Hexadehydro-16,20-Dimethyl-Delta 6(9A)-9(O)-Methano-Pr Ostaglandin I1
CAS No.	130273-99-3
Molecular Formula	C23H32O4
Molecular Weight	372.50 g/mol
Synonyms	16,20-Dimethyl-δ6(9α)-9-O-methano-PGI1; 9-O-Methano-δ6(9α)-PGI1, 16,20-dimethyl-; 16,20-Dimethyl-9α-methano-δ6-PGI1; Prostacyclin I1 analogue; PGI1 derivative; UNII-8VZQ7A9K6P; 4,5,18,18,19,19-Hexadehydro-16,20-dimethyl-δ6(9α)-9-O-methanoprostaglandin I1
EINECS	Contact for details

Quality Control

Our 4,5,18,18,19,19-Hexadehydro-16,20-Dimethyl-Delta 6(9A)-9(O)-Methano-Pr Ostaglandin I1 is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research and development applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.