Description

10-Hydroxycamptothecin is a potent, naturally derived topoisomerase I inhibitor with significant antitumor activity. This compound is a key intermediate and active pharmaceutical ingredient (API) in the research and development of novel chemotherapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories, biotechnology firms, and academic institutions focused on oncology drug discovery and advanced cancer therapeutics.

Application

• Primary active pharmaceutical ingredient (API) in the synthesis of advanced anticancer drugs.
• Critical reference standard and building block for pharmaceutical R&D in oncology.
• Key intermediate for the development of water-soluble camptothecin analogs (e.g., Irinotecan, Topotecan).
• Biochemical research tool for studying topoisomerase I inhibition mechanisms.
• Pre-clinical evaluation of antitumor efficacy in various cancer cell lines and animal models.
• Component in combination therapy research to overcome drug resistance.
• Starting material for the preparation of drug-loaded nanoparticles and targeted delivery systems.

Basic Information

Product Name	10-Hydroxycamptothecin
CAS No.	130194-92-2
Molecular Formula	C20H16N2O5
Molecular Weight	364.35 g/mol
Synonyms	10-HCPT; (S)-10-Hydroxycamptothecin; 10-Hydroxy-20(S)-camptothecin; NSC 107124; (19S)-10-Hydroxy-19-ethyl-1,16-dioxo-2,17-diazapentacyclo[11.8.0.0³,¹¹.0⁴,⁸.0¹⁴,¹⁹]henicosa-4,6,8,10,12-pentaene-20-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our 10-Hydroxycamptothecin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by IR and NMR spectroscopy, to ensure it meets high-purity standards suitable for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with specified parameters.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (20S-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.