Description

Pegaspargase is a modified form of the enzyme L-asparaginase, conjugated with monomethoxypolyethylene glycol (PEG) to enhance its pharmacokinetic profile. This modification is critical for reducing immunogenicity and prolonging the drug's half-life in the bloodstream, thereby improving therapeutic efficacy and patient tolerance. It is an essential chemotherapeutic agent primarily required by pharmaceutical manufacturers and research institutions developing and producing treatments for acute lymphoblastic leukemia (ALL).

Application

• Oncological Therapeutics: Primary use in the treatment of acute lymphoblastic leukemia (ALL), particularly in patients who have developed hypersensitivity to native forms of L-asparaginase.
• Pharmaceutical Formulation: Serves as the active pharmaceutical ingredient (API) in injectable drug products for chemotherapy.
• Clinical Research: Used in preclinical and clinical studies investigating new combination therapies or treatment protocols for hematological cancers.
• Biopharmaceutical Development: Employed as a model compound in research focused on PEGylation technologies and protein conjugation strategies to improve drug properties.

Basic Information

Product Name	Pegaspargase
CAS No.	130167-69-0
Molecular Formula	C1370H2108N362O421S8 (Representative)
Molecular Weight	~ 70,000 Da (Conjugate)
Synonyms	PEG-L-Asparaginase; PEG-Asparaginase; Oncaspar; L-Asparaginase PEG conjugate; Polyethylene Glycol-conjugated L-Asparaginase; Monomethoxypolyethylene Glycol Succinimidyl Succinate Modified L-Asparaginase; Pegylated Asparaginase; 130167-69-0
EINECS	Contact for details

Quality Control

Our Pegaspargase is manufactured under strict quality systems suitable for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including assessment of enzymatic activity, protein content, PEGylation ratio, and purity profiles. We provide full traceability and support regulatory submissions with comprehensive documentation. Certificates of Analysis (COA) detailing all release specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). Do not freeze. For long-term storage, keep under recommended conditions in original packaging.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or solid
Identification (HPLC/Activity)	Conforms
Protein Content (Biuret)	≥ 95.0%
Enzymatic Activity	As per COA
Purity (SDS-PAGE / SEC-HPLC)	≥ 98.0%
Free L-Asparaginase	≤ 1.0%
PEG Content	As per COA
pH (in solution)	6.5 - 7.5
Endotoxin (LAL)	< 1.0 EU/mg
Sterility (Membrane Filtration)	Sterile
Residual Moisture (KF)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.