Description

7-Ethyl-10-Hydroxycamptothecin is a potent semi-synthetic derivative of the natural alkaloid camptothecin, belonging to the topoisomerase I inhibitor class. Its primary value lies in its role as the active metabolite of the widely used chemotherapeutic agent Irinotecan (CPT-11), making it a critical intermediate and reference standard in oncology research and pharmaceutical development. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors focused on anticancer drug discovery, pharmacokinetic studies, and quality control of related therapeutics.

Application

• Pharmaceutical Intermediate: Key active metabolite and reference compound in the synthesis and quality control of the anticancer drug Irinotecan (CPT-11).
• Biomedical Research: Vital reference standard for in vitro and in vivo studies investigating topoisomerase I inhibition, mechanism of action, and resistance profiles.
• Drug Metabolism & Pharmacokinetics (DMPK): Used as an analytical standard to quantify SN-38 levels in biological matrices during preclinical and clinical studies of Irinotecan.
• Oncology Drug Discovery: Serves as a lead compound and benchmark for developing novel camptothecin analogs and combination therapies.
• Quality Control & Analytical Testing: Employed in HPLC, LC-MS, and other analytical methods to ensure the purity and potency of Irinotecan API and finished dosage forms.
• Academic Research: Used in university and institutional labs for fundamental cancer biology and chemotherapy research.

Basic Information

Product Name	7-Ethyl-10-Hydroxycamptothecin
CAS No.	130144-34-2
Molecular Formula	C22H20N2O5
Molecular Weight	392.41 g/mol
Synonyms	SN-38; 7-Ethyl-10-hydroxycamptothecin; 10-Hydroxy-7-ethylcamptothecin; (S)-10-Hydroxy-7-ethylcamptothecin; Irinotecan Metabolite; CPT-11 Active Metabolite; 7-Ethyl-10-hydroxy-20(S)-camptothecin; NSC 669133
EINECS	Contact for details

Quality Control

Our 7-Ethyl-10-Hydroxycamptothecin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm the (S)-configuration, and identification via IR and MS. We provide full traceability and Certificates of Analysis (COA) detailing all specifications. Our quality commitment ensures the material meets the stringent requirements for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and potency. Keep the container in a dry, cool, and well-ventilated area.

Specification

Item	Specification
Appearance	Yellow to light yellow powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.