Description

2-Hydroxy-5-Trifluoromethyl-Pyridine-3-Carbaldehyde is a high-value trifluoromethylated pyridine derivative, serving as a versatile and critical building block in advanced organic synthesis. Its unique structure, combining an aldehyde group with a hydroxyl and a trifluoromethyl substituent, makes it indispensable for creating complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for creating novel chelating ligands and organocatalysts used in asymmetric synthesis and metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing characteristics.
• Chemical Biology Probes: Utilized to develop fluorescent tags and molecular probes for studying biological processes and enzyme mechanisms.

Basic Information

Product Name	2-Hydroxy-5-Trifluoromethyl-Pyridine-3-Carbaldehyde
CAS No.	129904-48-9
Molecular Formula	C7H4F3NO2
Molecular Weight	191.11 g/mol
Synonyms	5-(Trifluoromethyl)-2-hydroxynicotinaldehyde; 3-Formyl-5-(trifluoromethyl)-2-pyridinol; 2-Hydroxy-5-(trifluoromethyl)pyridine-3-carboxaldehyde; 2-Pyridinol, 3-formyl-5-(trifluoromethyl)-; 5-Trifluoromethyl-2-hydroxypyridine-3-carbaldehyde; 3-Carbaldehyde-2-hydroxy-5-trifluoromethylpyridine; 2-Hydroxy-5-trifluoromethylnicotinaldehyde
EINECS	Contact for details

Quality Control

Every batch of 2-Hydroxy-5-Trifluoromethyl-Pyridine-3-Carbaldehyde is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and IR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.