Description

Y27632 (Hydrochloride) is a potent and selective inhibitor of Rho-associated coiled-coil containing protein kinase (ROCK). This compound is a critical research tool for investigating cellular processes involving the Rho/ROCK signaling pathway, such as cytoskeletal dynamics, cell adhesion, and motility. It is essential for researchers in pharmaceutical development, cell biology, and neuroscience, where precise modulation of this pathway is required for studying conditions like cardiovascular disease, glaucoma, and neurological disorders.

Application

• Biomedical Research: A key reagent for studying the role of ROCK in cell contraction, morphology, and migration in various disease models.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in high-throughput screening and target validation for ROCK inhibitor programs.
• Neuroscience Studies: Applied in research on axon guidance, neurite outgrowth, and neural regeneration following injury.
• Cardiovascular Research: Investigated for its effects on vascular smooth muscle contraction, blood pressure regulation, and endothelial function.
• Ophthalmology Research: Utilized in studies targeting intraocular pressure and the outflow pathway for potential glaucoma therapeutics.
• Stem Cell Differentiation: Employed to modulate the cytoskeleton to improve the efficiency of differentiating stem cells into specific lineages.

Basic Information

Product Name	Y27632 (Hydrochloride)
CAS No.	129830-38-2
Molecular Formula	C₁₄H₂₁N₅O • HCl
Molecular Weight	320.82 g/mol
Synonyms	Y-27632 dihydrochloride; (R)-(+)-trans-N-(4-Pyridyl)-4-(1-aminoethyl)-cyclohexanecarboxamide dihydrochloride; ROCK Inhibitor Y27632; Y 27632; Fasudil hydrochloride analog; Rho kinase inhibitor Y27632; (1R,4r)-4-((R)-1-Aminoethyl)-N-(pyridin-4-yl)cyclohexanecarboxamide dihydrochloride
EINECS	Contact for details

Quality Control

Our Y27632 (Hydrochloride) is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to high-purity research-grade standards, with typical purity exceeding 98% as determined by HPLC. Certificates are available upon request to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.