Description

Dofequidar is a high-purity, small-molecule pharmaceutical compound with significant research and development interest. This compound is valued for its potential role as a multidrug resistance (MDR) reversal agent, making it a critical component in advanced oncology and pharmacology studies. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) for the development of novel therapeutic formulations.

Application

• Primary research as a P-glycoprotein (P-gp) inhibitor to overcome multidrug resistance in cancer cells.
• Development of combination therapies to enhance the efficacy of chemotherapeutic agents.
• Use as a reference standard in analytical method development and validation for quality control laboratories.
• Preclinical and pharmacological studies investigating drug transport mechanisms.
• Chemical synthesis as a key intermediate or building block for more complex pharmaceutical molecules.
• Formulation research for improving drug bioavailability and targeted delivery systems.

Basic Information

Product Name	Dofequidar
CAS No.	129716-58-1
Molecular Formula	C32H35N3O5
Molecular Weight	541.64 g/mol
Synonyms	MS-209; Dofequidar fumarate; MS 209; (3R,4R)-3-({(3S)-3-[4-(3-Methoxyphenyl)-1-piperazinyl]-3-oxopropyl}amino)-2,2-dimethyl-4-phenyl-3,4-dihydro-2H-1-benzopyran-8-carboxamide; MS-209 free base; Benzopyran-8-carboxamide, 3,4-dihydro-3-[[(3S)-3-[4-(3-methoxyphenyl)-1-piperazinyl]-3-oxopropyl]amino]-2,2-dimethyl-4-phenyl-, (3R,4R)-
EINECS	Contact for details

Quality Control

Our Dofequidar is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification, assay, and impurity profiling via advanced techniques like HPLC and mass spectrometry. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.