Description

Minalrestat is a potent and selective aldose reductase inhibitor (ARI) with the CAS registry number 129688-50-2. This compound is of significant interest in pharmaceutical research for its potential to prevent or delay the onset of diabetic complications, particularly neuropathy, retinopathy, and nephropathy. It is primarily utilized by pharmaceutical R&D departments, contract research organizations (CROs), and academic institutions engaged in metabolic disorder and diabetes research.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of advanced drug candidates targeting diabetic complications.
• Biochemical Research: Used as a reference standard and tool compound in enzymatic assays to study aldose reductase inhibition and its biochemical pathways.
• Preclinical Development: Employed in animal model studies to evaluate the efficacy and pharmacokinetics of novel therapeutic agents for diabetes.
• Mechanistic Studies: Facilitates research into the polyol pathway and its role in hyperglycemia-induced cellular damage.
• Analytical Standard: Provides a high-purity standard for method development and quality control in analytical laboratories (HPLC, LC-MS).

Basic Information

Product Name	Minalrestat
CAS No.	129688-50-2
Molecular Formula	C17H14F3NO3S
Molecular Weight	369.36 g/mol
Synonyms	WAY-121,509; WAY 121509; (S)-6-Fluoro-2,3-dihydrospiro[4H-1-benzopyran-4,4'-imidazolidine]-2',5'-dione; (S)-6-Fluoro-2,3-dihydrospiro[chromene-4,4'-imidazolidine]-2',5'-dione; Minalrestat (WAY-121509); Aldose Reductase Inhibitor WAY-121509
EINECS	Contact for details

Quality Control

Our Minalrestat is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.