Description

N,n-Dimethylstaurosporine is a potent and selective derivative of the natural product staurosporine, specifically engineered for enhanced biological activity and research utility. This compound is a critical tool for investigating cellular signaling pathways, particularly those involving protein kinase inhibition. It is primarily utilized by researchers and scientists in the pharmaceutical, biotechnology, and academic sectors for drug discovery and biochemical studies. The product is supplied with a focus on high purity and batch-to-batch consistency to ensure reliable experimental results.

Application

• Biochemical Research: Used as a potent and selective protein kinase C (PKC) inhibitor in mechanistic studies of cell signaling, proliferation, and apoptosis.
• Pharmaceutical R&D: Serves as a key reference standard and lead compound in the discovery and development of novel kinase-targeted therapeutics for cancer and other diseases.
• Cell Biology Studies: Employed to modulate specific kinase activity in cell culture models to understand pathway function and validate drug targets.
• Academic Research: A fundamental reagent in university and institutional laboratories for graduate and post-doctoral research projects in molecular biology and pharmacology.

Basic Information

Product Name	N,n-Dimethylstaurosporine
CAS No.	129623-30-9
Molecular Formula	C30H30N4O3
Molecular Weight	494.59 g/mol
Synonyms	7-Oxo-7H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5-carboxylic acid, 2,3,10,11,12,13-hexahydro-10,11-dihydroxy-9-methyl-2-(1-methylethyl)-, methyl ester, (9S,10R,11R,13R)-; N,N-Dimethylstaurosporine; 4'-N-Methyl-5'-N-methylstaurosporine; Staurosporine, N,N-dimethyl-; CGP 41251; PKC 412 (Midostaurin) related compound
EINECS	Contact for details

Quality Control

Our N,n-Dimethylstaurosporine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation, NMR and MS for structural verification, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our commitment is to deliver material of the highest consistency for critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. The product is light-sensitive and should be handled under appropriate conditions to prevent degradation. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.