Description

(1'Rs,2'S)-Nicotine 1,1'-Di-n-Oxide CAS NO 129547-84-8 is a specific stereoisomer of nicotine di-N-oxide, a key derivative of nicotine. This compound is of significant interest in advanced research and development, particularly for its potential as a high-purity reference standard and a sophisticated synthetic intermediate. It is primarily utilized by pharmaceutical R&D laboratories, analytical service providers, and specialty chemical manufacturers engaged in the study of nicotinic analogs, metabolite profiling, and novel synthetic pathways.

Application

• Pharmaceutical Reference Standard: Serves as a certified analytical standard for method development, validation, and quality control in the analysis of nicotine and its metabolites.
• Metabolite Research: Used as a key reference material in pharmacokinetic and metabolic pathway studies related to nicotine and tobacco alkaloids.
• Advanced Synthetic Intermediate: Employed in the research-scale synthesis of more complex nicotine derivatives and analogs for biological screening.
• Biochemical Research: Utilized in studies investigating the binding affinity and functional activity at nicotinic acetylcholine receptors (nAChRs).
• Analytical Chemistry: Acts as a critical component in developing and calibrating advanced analytical techniques like LC-MS/MS and HPLC for alkaloid detection.

Basic Information

Product Name	(1'Rs,2'S)-Nicotine 1,1'-Di-n-Oxide
CAS No.	129547-84-8
Molecular Formula	C10H14N2O2
Molecular Weight	194.23 g/mol
Synonyms	(1'R,2'S)-Nicotine Di-N-Oxide; (-)-Nicotine Di-N-Oxide; (S)-Nicotine Di-N-Oxide; Nicotine 1,1'-Dioxide; Nicotine Di-N-Oxide; 3-[(2S)-1-Methyl-2-pyrrolidinyl]pyridine 1,1'-Dioxide; (S)-(-)-Nicotine Di-N-Oxide; Pyridine, 3-[(2S)-1-methyl-2-pyrrolidinyl]-, 1,1'-dioxide
EINECS	Contact for details

Quality Control

Our (1'Rs,2'S)-Nicotine 1,1'-Di-n-Oxide is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including chiral purity verification and impurity profiling. A Certificate of Analysis (COA) detailing identity, assay, chiral purity, and related substances is provided with every shipment to support your research and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.