Description

D-Threo-Ritalinic Acid CAS NO 129389-67-9 is a key chiral intermediate and the primary metabolite of the central nervous system stimulant methylphenidate. This compound is of significant importance in pharmaceutical research and development, particularly for analytical and metabolic studies. It serves as a critical reference standard for pharmacokinetic investigations and quality control in the production of related active pharmaceutical ingredients (APIs). Industries requiring this high-purity chemical include pharmaceutical R&D, analytical laboratories, and fine chemical synthesis.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and identification of methylphenidate and its metabolites in biological matrices.
• Metabolite Studies: Essential for in-vitro and in-vivo pharmacokinetic and pharmacodynamic research related to stimulant medications.
• Analytical Method Development: Serves as a critical component in developing and validating HPLC, LC-MS, and GC-MS methods for forensic and clinical toxicology.
• Active Pharmaceutical Ingredient (API) Synthesis: Acts as a chiral building block or intermediate in the synthesis of specialized pharmaceutical compounds.
• Quality Control & Assurance: Employed in pharmaceutical quality control laboratories to ensure the purity and consistency of drug substances and products.
• Biochemical Research: Used in studies investigating neurotransmitter reuptake inhibition mechanisms and related neurological pathways.

Basic Information

Product Name	D-Threo-Ritalinic Acid
CAS No.	129389-67-9
Molecular Formula	C14H19NO2
Molecular Weight	233.31 g/mol
Synonyms	(2R,2'R)-2-Phenyl-2-(2-piperidin-2-yl)acetic acid; D-threo-Methylphenidate acid; D-threo-Ritalinic acid; α-Phenyl-α-(2-piperidyl)acetic acid, (R,R)-(-)-form; Ritalinic Acid, D-threo-; Methylphenidate Metabolite; (R,R)-(-)-three-Methylphenidate acid
EINECS	Contact for details

Quality Control

Our D-Threo-Ritalinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and reference materials. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-threo isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.