Description

D-Myo-Inositol 1,4,5-Tris-Phosphate, 3-Deoxy-3-Fluor is a fluorinated analog of the critical second messenger, inositol 1,4,5-trisphosphate (IP3). This compound matters as a potent and selective biochemical tool for probing the structure and function of IP3 receptors in cellular calcium signaling pathways. It is essential for researchers and developers in pharmaceutical discovery, molecular biology, and biochemical research who require high-purity, well-characterized probes to study calcium-dependent processes and develop targeted therapies.

Application

• Biochemical Research: As a stable, hydrolysis-resistant analog of IP3 for studying receptor binding, activation kinetics, and calcium release mechanisms in cell-free systems and permeabilized cells.
• Pharmaceutical Development: A key tool compound in high-throughput screening (HTS) assays to identify and characterize novel modulators (agonists/antagonists) of the IP3 receptor for therapeutic intervention.
• Signal Transduction Studies: Used to investigate the role of IP3-mediated calcium signaling in critical cellular processes such as apoptosis, gene transcription, muscle contraction, and neuronal function.
• Enzymology: Serves as a substrate analog to study the specificity and inhibition of phosphatases and kinases involved in the inositol phosphate metabolic pathway.
• Probe Synthesis: Acts as a precursor or core structure for the synthesis of more complex, labeled probes (e.g., fluorescent, photoaffinity, or radiolabeled) for advanced imaging and binding studies.

Basic Information

Item	Details
Product Name	D-Myo-Inositol 1,4,5-Tris-Phosphate, 3-Deoxy-3-Fluor
CAS No.	129365-68-0
Molecular Formula	C6H12FO15P3
Molecular Weight	508.06 g/mol
Synonyms	3-Deoxy-3-fluoro-D-myo-inositol 1,4,5-trisphosphate; 3-Fluoro-IP3; 3-F-IP3; Fluorinated IP3; D-myo-Inositol 1,4,5-trisphosphate 3-fluoro analog; Ins(1,4,5)P3 3-F analog; 1D-myo-Inositol 1,4,5-trisphosphate, 3-deoxy-3-fluoro-; IP3 Fluoro Analog
EINECS	Contact for details

Quality Control

Our high-purity biochemical grade products are manufactured under controlled conditions and undergo rigorous analytical characterization. Each batch is tested to ensure identity, purity, and consistency, with comprehensive data provided. Certificates of Analysis (COA) detailing results from NMR, HPLC, and mass spectrometry are available upon request to support your research and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture absorption. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.