Description

Oxazofurin is a synthetic nucleoside analog with significant research and development interest in the life sciences sector. Its primary value lies in its role as a potent inhibitor of inosine monophosphate dehydrogenase (IMPDH), a key enzyme in the *de novo* biosynthesis of guanine nucleotides. This mechanism makes it a critical compound for researchers in pharmaceutical development, particularly for investigating antiviral, anticancer, and immunosuppressive therapeutic pathways. Global B2B clients in fine chemical synthesis, biotechnology, and advanced pharmaceutical R&D utilize this high-purity intermediate.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel IMPDH inhibitors.
• Antiviral Agent Studies: Investigated for its potential activity against a range of viral pathogens by disrupting viral RNA synthesis.
• Oncology Research: Used in preclinical studies to explore its antiproliferative effects on various cancer cell lines due to its inhibition of nucleotide synthesis.
• Immunosuppression Research: A tool compound for studying the modulation of lymphocyte proliferation and function in autoimmune disease models.
• Biochemical Assay Development: Employed as a specific enzyme inhibitor in high-throughput screening (HTS) assays targeting IMPDH.
• Fine Chemical Synthesis: Used as a sophisticated building block for the synthesis of more complex nucleoside-derived compounds.

Basic Information

Product Name	Oxazofurin
CAS No.	129149-89-9
Molecular Formula	C11H15N3O6
Molecular Weight	285.25 g/mol
Synonyms	3-β-D-Ribofuranosylthiazolo[4,5-c]pyridin-2-one; 3-(β-D-Ribofuranosyl)thiazolo[4,5-c]pyridin-2(3H)-one; NSC 356894; Oxazofurine; IMPDH Inhibitor II; Thiazolo[4,5-c]pyridin-2-one, 3-β-D-ribofuranosyl-
EINECS	Contact for details

Quality Control

Every batch of Oxazofurin is manufactured under strict quality management systems. We provide material that meets high-purity standards suitable for research and development applications. Comprehensive analytical testing, including HPLC for purity and identity confirmation, is performed. A Certificate of Analysis (COA) detailing batch-specific results is available for all orders, ensuring traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. Ensure the container is sealed under inert atmosphere after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.